Tissue healing and regenerating abilities of raw honey

March 11, 2021

Tissue healing and regenerating abilities of raw honey

By Hamad Shafqat

While honey tastes great with oatmeal or toast, the benefits of honey are almost infinite besides sweetening. People have been using raw honey because of its therapeutic properties since ancient times. If you buy honey from the grocery store, it does not contain beneficial nutrients because it is often pasteurized. Raw and unpasteurized honey has both health benefits and medical uses. 

Raw honey is an aromatic, sweet, and viscous food with antioxidant, anti-inflammatory, and antibacterial properties. Besides the kitchen cabinet, honey is being used as a “wound dressing.” Many of you still do not know about the wound-care properties of honey, but it is true that honey can help a wound heal properly, treat burns and bacterial infections (1).  

Let’s have a look at how honey heals wounds and regenerates tissues. 

How Does Honey Aids In Tissue Healing And Regeneration?

Honey possesses immunomodulatory properties to boost wound healing and tissue regeneration. It acts as an antibacterial agent to hinder the growth of microorganisms, such as fungi and bacteria. The U.S. FDA approved Honey for treating wounds (2)

Honey heals tissues and protects them from microbes by two antibacterial mechanisms:

 1. Inhibition Microbial Growth: Honey releases hydrogen peroxide as an antiseptic, which significantly prevents the growth of any bacteria on the wound (3).  

2. Non-Peroxide Activity: Flavonoids (organic acids and phenols) present in honey carry out their non-peroxidase activity to inhibit the growth of bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), E. coli, and Pseudomonas aeruginosa (4)

Honey aids in wound healing and tissue regeneration by:

1. Acidic PH: Your blood releases oxygen in the presence of acidic PH of honey. The acidic PH of honey ranges from 3.3 to 4.5, and when applied to wounds, it promotes healing. Proteases are also present on wounds and tend to impair the wound healing process. The acidic PH of honey prevents the activity of destructive proteases and regulates natural wound healing (5)

2. High Osmolarity: The high sugar content of honey tends to draw fluid out of the damaged wound tissues; this is called the osmotic effect. The high osmolarity of honey increases the outflow of lymph and reduces swelling, which helps heal the tissue. High osmolarity also prevents bacteria from multiplying on the wounds (6)

How Honey Minimizes Scarring?

Raw honey is also helpful for minimized scar formation because of its natural wound healing properties. Honey replaces the damaged tissues with the new ones by process of regeneration. Regenerated tissues minimize scarring without causing any stiffness and pain. Applying honey formulated creams on spots and scars regularly can help you get rid of scars because it clears and cleanses the wounds (7)

Which Type Of Honey Is Preferred For Wound Healing?

Raw honey is used for wound healing and tissue regeneration because of its potential cytotoxic, pro-inflammatory properties and the presence of MGO (methylglyoxal). Raw Honey is derived from a diverse array of plants, which provides its bioactivity. The bioactivity of honey activates the immune response, which helps in the regeneration of tissues on the wound bed (8).  Raw Honey treats:

  • Wounds and burns
  • Bacterial infections
  • Boils
  • Diabetic foot ulcers
  • Pilonidal sinus


Since the time of ancient civilizations, raw honey has been used as a therapeutic agent with infinite benefits. From treating bacterial infections to minimizing scarring and regenerating tissues, raw honey possesses antimicrobial and antibacterial properties. 

Natural Skin Treatment

When it comes to treating skin conditions naturally, there are many options to consider. Honeyderm has a range of products that are specifically formulated to naturally support healthy skin - with the miraculous restorative power of honeybees. 

Dermatonic™ A is a natural acne treatment that provides your skin with essential supplements, immune stimulants, antioxidants, and antimicrobial activities.

Dermatonic™ W supports a balanced epidermal activity to avoid the development of predisposing conditions for wrinkles.

You can combine this with the Honeyderm™ Honey & Turmeric soap is a balanced soap formula that provides deep skin cleansing while promoting skin healing through its 100% natural additives of honey, black seed oil, olive oil, emu oil, and green tea. These healing ingredients place Honeyderm™ Honey & Turmeric soap ahead of any other soap or skin cleanser. 


  1. P, Rhodes, T. Honey: A Biologic Wound Dressing.  2015 June;27;6: 1044-7946. Available from:
  2. 7 Proven Benefits and Uses of Manuka Honey [Internet]. Healthline. 2018 [cited 2021 Mar 1]. Available from:
  3. Martinotti S, Ranzato E. Honey, Wound Repair and Regenerative Medicine. J Funct Biomater [Internet]. 2018 May 8 [cited 2021 Mar 1];9(2). Available from:
  4. Irish J, Blair S, Carter DA. The antibacterial activity of honey derived from Australian flora. PloS One. 2011 Mar 28;6(3):e18229.
  5. Honey on Wounds: When, How, Safety, and Effectiveness [Internet]. Healthline. 2018 [cited 2021 Mar 1]. Available from:
  6. Al-Waili N, Salom K, Al-Ghamdi AA. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. ScientificWorldJournal. 2011 Apr 5;11:766–87.
  7. Yaghoobi R, Kazerouni A, kazerouni O. Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review. Jundishapur J Nat Pharm Prod. 2013 Aug;8(3):100–4.
  8. Mavric E, Wittmann S, Barth G, Henle T. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res. 2008 Apr;52(4):483–9.

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