Role Of Antioxidants In Tissue Healing

June 29, 2021

Role Of Antioxidants In Tissue Healing

By Sam Musa PharmD

Tissue healing is an important mechanism to maintain the body’s integrity and function. Sometimes, the body’s natural tissue healing process is delayed because of free radicals, which can damage the healthy cells of tissues. Antioxidants have been proven to be efficient in contributing to tissue healing. Antioxidants, also called “free radical scavengers,” recreate the optimal environment for tissues to heal properly. 

Let’s first talk about what antioxidants are and how antioxidants from different food sources facilitate tissue healing. 

What Are Antioxidants?

Antioxidants are molecules that destroy or reduce the concentration of free radicals in your body, thereby encouraging tissue repair in wounds. Your body has its own antioxidants that defend your body against free radicals. 

Free radicals, also called reactive oxygen species (ROS), are waste and unstable substances that cause damage to the cell in your body and affect the body’s function (1).

The food sources that are rich in antioxidants pertaining to tissue healing include:

  • Fruits
  • Leafy greens
  • Turmeric
  • Honey
  • Camellia sinensis (green tea)
  • Ginger

 How Antioxidants Help in Tissue Healing?

The wound healing process involves four stages:

  • Hemostasis
  • Inflammation
  • Proliferation
  • Remodeling 

Free radicals cause oxidative stress at the wound site, which starts destroying the tissues in the wound. Significant damage to healthy cells of the tissue at the wound site causes a delay in tissue healing and regeneration.  

Antioxidants promote tissue healing by quenching free radicals and decreasing oxidative stress exposure at the wound site. Tissue healing is accelerated when you start intaking adequate food sources rich in antioxidants throughout the tissue healing process. Antioxidants also:

  • Improve the tissue healing outcome
  • Reduce inflammation at the wound site
  • Facilitate the regeneration of healthy tissues (2) 

Here’s how antioxidants from different food sources help in tissue healing:

Antioxidants In Raw Honey: Raw honey contains vitamin C, polyphenolics, flavonoids, and monophenolics as natural antioxidants. These antioxidants help in decreasing inflammation during the tissue healing process. In addition to being used as a wound dressing, raw honey also reduces the foul smell emanating from wounds (3).

Antioxidants In Green Tea: Camellia Sinensis, also called green tea, is packed with catechin compounds that enhance the tissue healing process by increasing collagen volume. One study reported that the wound site dressed with green tea showed less inflammation and collagen. Green tea is considered most effective in healing surgical wounds (4,5).

Antioxidants In Turmeric: Curcumin present in turmeric is an antioxidant known to enhance the tissue healing process. Curcumin possesses anti-inflammatory, anti-microbial, radical scavenger, and antioxidant properties and causes the synthesis of growth hormones to accelerate the tissue regeneration process. 

Curcumin decreases your body’s response to cutaneous wounds, such as oxidative stress and inflammation, so that tissues can repair and heal more quickly. Topical application of turmeric on the wound or oral administration is associated with enhanced tissue healing activity (6).

Antioxidants In Ginger: Ginger is packed with shogaol, gingerols, and paradols that act as anti-inflammatory and antioxidant agents. Gingerols strengthen the body’s defenses against free radicals, thereby preventing inflammation at the wound site. Ginger is known to promote tissue regeneration more quickly by reducing oxidative stress within the cells of tissues (7)


Healing Ingredients

Honeyderm products utilize the healing power of raw honey and medicinal plants like green tea, turmeric and ginger. The pharmacists at Honeyderm choose only the highest caliber of natural ingredients to formulate skin products like the DermatonicP and DermatonicWash.

Unlike other products found on the market, Dermatonic™ P and Dermatonic™ Wash supports eczema and psoriasis treatment and does not include any drug or steroid.  Dermatonic™ P is made from the purest herbs, honey, and beehive ingredients - carefully formulated into a complete, natural product. The beehive ingredients themselves exhibit remarkable activities such as:

  • Tissue healing and regeneration
  • Immune stimulation
  • Anti-inflammatory activity
  • Antimicrobial activity
  • Antioxidant activity

The results of Dermatonic™ P and Wash are quickly noticeable within the first few applications. Signs of itching and inflammation are the first to be noticed. Lesions are then gradually diminished and healthy tissue replaces the affected areas until cells are fully recovered. Dermatonic™ P and Wash have helped many people regain their confidence and enjoy their beautiful skin which they have missed for long periods of time.


  1. Underdown MJ. Antioxidants and Wound Healing. 2013
  2. Fitzmaurice SD, Sivamani RK, Isseroff RR. Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products. Skin Pharmacol Physiol. 2011;24(3):113–26.
  3. Yaghoobi R, Kazerouni A, kazerouni O. Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Antioxidant and Anti-viral Agent: A Review. Jundishapur J Nat Pharm Prod. 2013 Aug;8(3):100–4.
  4. Asadi SY, Parsaei P, Karimi M, Ezzati S, Zamiri A, Mohammadizadeh F, et al. Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. Int J Surg. 2013 May 1;11(4):332–7.
  5. Hajiaghaalipour F, Kanthimathi MS, Abdulla MA, Sanusi J. The Effect of Camellia sinensis on Wound Healing Potential in an Animal Model. Evid-Based Complement Altern Med ECAM. 2013;2013:386734.
  6. Tejada S, Manayi A, Daglia M, Nabavi SF, Sureda A, Hajheydari Z, et al. Wound Healing Effects of Curcumin: A Short Review. Curr Pharm Biotechnol. 2016;17(11):1002–7.
  7. Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. Int J Prev Med. 2013 Apr;4(Suppl 1):S36–42.



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